Abstract: In modern lifestyles, people are affected by shifts, light pollution, lack of sleep and irregular mealtimes, causing chronic dissynchronization between internal clocks and the environment, which can lead to disrupted circadian rhythms. When circadian rhythms are disrupted or maladjusted, they can have adverse health consequences and increase the risk of diseases such as cancer, cardiovascular disease or metabolic disorders. In recent years, a wide range of animal models of circadian rhythm disorders have been established by means of core gene knockout, chemical induction, physical and dietary intervention, etc. In this paper, we summarized the commonly used animal models of circadian rhythm disorders, and briefly summarized the pathogenesis of circadian rhythm disorders.

Key words: circadian clock disorder, experimental animal models, central circadian clock, peripheral circadian clock

摘要： 在现代生活方式下,人们受到轮班、光污染、睡眠不足和进餐时间不规律等因素的影响,引起内部时钟和环境 之间长期不同步,从而导致昼夜节律紊乱,当昼夜节律受到干扰或失调时,就会产生不利的健康后果,并增加癌症、 心血管疾病或代谢紊乱等患病风险。 近年来,通过核心基因敲除、化学诱导、物理和饮食干预等方法,建立了广泛 的昼夜节律紊乱动物模型,本文总结了常用的昼夜节律紊乱动物模型,并简要归纳了昼夜节律紊乱相关发病机制。

关键词: 昼夜紊乱, 实验动物模型, 中枢生物钟, 外周生物钟